Evidence-based medicine is the most prevalent paradigm adopted by physicians. Clinical
practice guidelines typically define a set of recommendations together with eligibility criteria …

The proposition of cancer cells in a tumor sample, named as tumor purity, is an intrinsic
factor of tumor samples and has potentially great influence in variety of analyses including …

Discovering cancer subtypes is useful for guiding clinical treatment of multiple cancers.
Progressive profile technologies for tissue have accumulated diverse types of data. Based …

Background With the advent of array-based techniques to measure methylation levels in
primary tumor samples, systematic investigations of methylomes have widely been …

Breast cancer prognosis is challenging due to the heterogeneity of the disease. Various
computational methods using bulk RNA-seq data have been proposed for breast cancer …

DNA methylation (DNAm) is a key epigenetic mark that shows profound alterations in
cancer. Read-level methylomes enable more in-depth analyses, due to their broad genomic …

Colorectal cancer (CRC) is a major global health concern, with a significant impact on
morbidity and mortality. The molecular mechanisms underlying CRC, especially DNA …

Tumor purity is the percentage of cancer cells within a tissue section. Pathologists estimate
tumor purity to select samples for genomic analysis by manually reading hematoxylin-eosin …

Diagnosing cancer and identifying the disease gene by using DNA microarray gene
expression data are the hot topics in current bioinformatics. This paper is devoted to the …

Recently, cancer has been characterized as a heterogeneous disease composed of many
different subtypes. Early diagnosis of cancer subtypes is an important study of cancer …