Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Psoriasis vulgaris is a chronic, immune-mediated, inflammatory, polygenic skin disorder
affecting approximately 2% of the population. It has a great impact on quality of life; patients …

Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …

Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and
synthetic organic compounds. Statistically, DE is the second most popular and enduring …

The nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORγ or RORc)
is a key transcription factor for the production of pro-inflammatory cytokines implicated in the …

RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH 17)
cell development. However, the cell-intrinsic mechanisms that negatively regulate TH 17 cell …

Introduction: The transcription factor retinoic acid-related orphan receptor gamma t (RORγt)
has been identified as the master regulator of TH17 cell differentiation and IL-17/22 …

The IL-17 cytokine family comprising IL-17A to IL-17F and receptor subunits IL-17RA to IL-
17RE represents a genetically ancient intercellular network regulating local tissue …

Retinoic acid–related orphan receptor (ROR)-γt, the master transcription factor of the Th17
subset of CD4+ Th cells, is a promising target for treating a host of autoimmune diseases …

Accumulating observations in humans and animals indicate that inflammation plays a key
role in atherosclerosis development and subsequent complications. Moreover, the use of …