Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging

K Yeh, I Sharma, K Falahkheirkhah, MP Confer… - Nature …, 2023 - nature.com
Chemical imaging, especially mid-infrared spectroscopic microscopy, enables label-free
biomedical analyses while achieving expansive molecular sensitivity. However, its slow …

Mid-infrared metabolic imaging with vibrational probes

L Shi, X Liu, L Shi, HT Stinson, J Rowlette, LJ Kahl… - Nature …, 2020 - nature.com
Understanding metabolism is indispensable in unraveling the mechanistic basis of many
physiological and pathological processes. However, in situ metabolic imaging tools are still …

All-digital histopathology by infrared-optical hybrid microscopy

M Schnell, S Mittal, K Falahkheirkhah… - Proceedings of the …, 2020 - National Acad Sciences
Optical microscopy for biomedical samples requires expertise in staining to visualize
structure and composition. Midinfrared (mid-IR) spectroscopic imaging offers label-free …

High-speed scanless entire bandwidth mid-infrared chemical imaging

Y Zhao, S Kusama, Y Furutani, WH Huang… - Nature …, 2023 - nature.com
Mid-infrared spectroscopy probes molecular vibrations to identify chemical species and
functional groups. Therefore, mid-infrared hyperspectral imaging is one of the most powerful …

Rapid hyperspectral photothermal mid-infrared spectroscopic imaging from sparse data for gynecologic cancer tissue subty**

R Reihanisaransari, CC Gajjela, X Wu… - Analytical …, 2024 - ACS Publications
Ovarian cancer detection has traditionally relied on a multistep process that includes biopsy,
tissue staining, and morphological analysis by experienced pathologists. While widely …

Concurrent vibrational circular dichroism measurements with infrared spectroscopic imaging

Y Phal, K Yeh, R Bhargava - Analytical chemistry, 2020 - ACS Publications
Vibrational circular dichroism (VCD) spectroscopy has emerged as a powerful platform to
quantify chirality, a vital biological property that performs a pivotal role in the metabolism of …

Microscale spectroscopic map** of 2d optical materials

X Dong, AK Yetisen, MH Köhler, J Dong… - Advanced Optical …, 2019 - Wiley Online Library
Abstract 2D materials have unique optical properties due to their ultrathin layered structures,
and are emerging as promising materials for optoelectronic devices. To characterize and …

[HTML][HTML] A decade of mid-infrared, 3.5 µm dual-wavelength pumped fiber lasers, review and perspective

O Henderson-Sapir, DJ Ottaway - APL Photonics, 2024 - pubs.aip.org
It has been a decade since dual-wavelength pum** revolutionized the efficiency and
power of the 3.5 µm transition in erbium-doped fluoride fibers, demonstrating the potential …

Deep learning-based protocols to enhance infrared imaging systems

K Falahkheirkhah, K Yeh, S Mittal, L Pfister… - Chemometrics and …, 2021 - Elsevier
Infrared (IR) spectroscopic imaging provides both morphologic and chemical detail;
however, obtaining this extensive spectral-spatial information requires the ability to rapidly …

Label-free infrared spectroscopic imaging reveals heterogeneity of β-sheet aggregates in Alzheimer's disease

MP Confer, BM Holcombe, AG Foes… - The journal of …, 2021 - ACS Publications
The aggregation of the amyloid beta (Aβ) protein into plaques is a pathological feature of
Alzheimer's disease (AD). While amyloid aggregates have been extensively studied in vitro …