AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which
coordinates metabolic pathways and thus balances nutrient supply with energy demand …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Dysregulation of histone lysine methyltransferases and demethylases is one of the major
mechanisms driving the epigenetic reprogramming of transcriptional networks in castration …

Background Enzalutamide is a novel antiandrogen with proven efficacy in metastatic
castration-resistant prostate cancer (mCRPC). Objective To evaluate enzalutamide's effects …

Prostate cancer is the second most common malignancy in men and androgen deprivation
therapy is the first‐line therapy. However, most cases will eventually develop castration …

In our effort to discover potent and specific inhibitors of 17α-hydroxylase/17, 20-lyase
(CYP17), the key enzyme which catalyzes the biosynthesis of androgens from progestins, 3β …

Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly
expressed on prostate cancer. Its expression correlates inversely with survival and …

While there are myriad mechanisms of primary and acquired resistance to conventional and
next-generation hormonal therapies in prostate cancer, the potential role of androgen …

Enzalutamide is a second-generation nonsteroidal antiandrogen clinically approved for the
treatment of castration-resistant prostate cancer (CRPC), yet resistance to endocrine therapy …

Neuroendocrine prostate cancer is a histological variant of prostate cancer that is
characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine …