Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …
among the most frequent causes of disability and death worldwide. Current treatment …
Neuronal cell death
Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …
especially important because of the limited capacity of adult neurons to proliferate or be …
Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities
Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …
Necrosis: a specific form of programmed cell death?
SY Proskuryakov, AG Konoplyannikov… - Experimental cell research, 2003 - Elsevier
For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …
Molecular targets in cerebral ischemia for develo** novel therapeutics
SL Mehta, N Manhas, R Raghubir - Brain research reviews, 2007 - Elsevier
Cerebral ischemia (stroke) triggers a complex series of biochemical and molecular
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …
mechanisms that impairs the neurologic functions through breakdown of cellular integrity …
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future
ML Hu, YR Pan, YY Yong, Y Liu, L Yu, DL Qin… - Ageing research …, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo
High mobility group proteins are chromatin binding factors with key roles in maintenance of
nuclear homeostasis. The evidence indicates that extracellularly released high mobility …
nuclear homeostasis. The evidence indicates that extracellularly released high mobility …
Poly (ADP‐ribose) polymerase‐1 activity promotes NF‐κB‐driven transcription and microglial activation: implication for neurodegenerative disorders
Excessive release of proinflammatory products by activated glia causes neurotoxicity and
participates in the pathogenesis of neurodegenerative disorders. Recently, poly (ADP …
participates in the pathogenesis of neurodegenerative disorders. Recently, poly (ADP …
In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
L Lossi, A Merighi - Progress in neurobiology, 2003 - Elsevier
Apoptosis has been recognized to be an essential process during neural development. It is
generally assumed that about half of the neurons produced during neurogenesis die before …
generally assumed that about half of the neurons produced during neurogenesis die before …
Nuclear poly (ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …