Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: A review
Colorectal cancer (CRC) is a major health concern with multifactorial pathophysiology
representing intense therapeutic challenges. It is well known that deregulation of …
representing intense therapeutic challenges. It is well known that deregulation of …
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy
AH Manickam, MJ Michael… - Indian Journal of …, 2017 - journals.lww.com
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder
that is characterized by the degeneration of the optic nerves, leading to vision loss. The …
that is characterized by the degeneration of the optic nerves, leading to vision loss. The …
Altered mitochondrial signalling and metabolism in cancer
Mitochondria being the central organelle for metabolism and other cell signalling pathways
have remained the topic of interest to tumour biologists. In spite of the wide acceptance of …
have remained the topic of interest to tumour biologists. In spite of the wide acceptance of …
Role of Smoking-Mediated molecular events in the genesis of oral cancers
Smoking is a pernicious practice prevalent worldwide. It involves breathing of burnt-tobacco
fumes/smoke which comprises of numerous chemical entities posing deleterious aftermaths …
fumes/smoke which comprises of numerous chemical entities posing deleterious aftermaths …
Mitochondrial DNA mutations in grade II and III glioma cell lines are associated with significant mitochondrial dysfunction and higher oxidative stress
The role of mitochondria in tumorigenesis has regained much attention as it could
dysregulate cellular energetics, oxidative stress and apoptosis. However, the role of …
dysregulate cellular energetics, oxidative stress and apoptosis. However, the role of …
The relevance of miRNAs as promising biomarkers in lip cancer
A Assao, MAC Domingues, EM Minicucci… - Clinical Oral …, 2021 - Springer
Objectives This study aimed to analyze the expression of miR-181b, miR-21, miR-31, and
miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell …
miR-345 in actinic cheilitis with and without epithelial dysplasia and lower lip squamous cell …
[HTML][HTML] iPSC culture expansion selects against putatively actionable mutations in the mitochondrial genome
Therapeutic application of induced pluripotent stem cell (iPSC) derivatives requires
comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) …
comprehensive assessment of the integrity of their nuclear and mitochondrial DNA (mtDNA) …
Benchmark dose analysis for PAHs hydroxyl metabolites in urine based on mitochondrial damage of peripheral blood leucocytes in coke oven workers in China
S Cheng, H Zhang, P Wang, K Zou, X Duan… - Environmental …, 2021 - Elsevier
Objectives The aim was to explore the dose-response relationship between occupational
polycyclic aromatic hydrocarbons (PAHs) exposure and mitochondrial damage in coke oven …
polycyclic aromatic hydrocarbons (PAHs) exposure and mitochondrial damage in coke oven …
Salivary biomarkers in oral cancer
P Panta, DTW Wong - Oral Cancer Detection: Novel Strategies and Clinical …, 2019 - Springer
Saliva is an easily accessible biofluid with immense diagnostic potential in oral cancer. The
identification of potential saliva signatures for early, noninvasive detection of oral squamous …
identification of potential saliva signatures for early, noninvasive detection of oral squamous …
Profiling of genomic alterations of mitochondrial DNA in gingivobuccal oral squamous cell carcinoma: Implications for disease progress
We have identified 164 somatic mutations in mitochondrial DNA in gingivobuccal oral
cancer by deep sequencing the mitochondrial genome from paired tumor and blood DNA …
cancer by deep sequencing the mitochondrial genome from paired tumor and blood DNA …