Novel roles of phosphoinositides in signaling, lipid transport, and disease
Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
Structural diversity within the endoplasmic reticulum—from the microscale to the nanoscale
The endoplasmic reticulum (ER) is a continuous, highly dynamic membrane compartment
that is crucial for numerous basic cellular functions. The ER stretches from the nuclear …
that is crucial for numerous basic cellular functions. The ER stretches from the nuclear …
Genetic pain loss disorders
Genetic pain loss includes congenital insensitivity to pain (CIP), hereditary sensory
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …
neuropathies and, if autonomic nerves are involved, hereditary sensory and autonomic …
Heteromeric clusters of ubiquitinated ER-sha** proteins drive ER-phagy
H Foronda, Y Fu, A Covarrubias-Pinto, HT Bocker… - Nature, 2023 - nature.com
Membrane-sha** proteins characterized by reticulon homology domains play an
important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of …
important part in the dynamic remodelling of the endoplasmic reticulum (ER). An example of …
Axonal endoplasmic reticulum dynamics and its roles in neurodegeneration
The physical continuity of axons over long cellular distances poses challenges for their
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike …
Defective lysosome reformation during autophagy causes skeletal muscle disease
MJ McGrath, MJ Eramo, R Gurung… - The Journal of …, 2021 - Am Soc Clin Investig
The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …
Functions of oxysterol-binding proteins at membrane contact sites and their control by phosphoinositide metabolism
F Nakatsu, A Kawasaki - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Lipids must be correctly transported within the cell to the right place at the right time in order
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …
to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer …
Oligomeric scaffolding for curvature generation by ER tubule-forming proteins
Y **ang, R Lyu, J Hu - nature communications, 2023 - nature.com
The reticulons and receptor expression-enhancing proteins (REEPs) in the endoplasmic
reticulum (ER) are necessary and sufficient for generating ER tubules. However, the …
reticulum (ER) are necessary and sufficient for generating ER tubules. However, the …
Complexity and specificity of Sec61-channelopathies: human diseases affecting gating of the Sec61 complex
M Sicking, S Lang, F Bochen, A Roos, JPH Drenth… - Cells, 2021 - mdpi.com
The rough endoplasmic reticulum (ER) of nucleated human cells has crucial functions in
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …
protein biogenesis, calcium (Ca2+) homeostasis, and signal transduction. Among the …
Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network
The hereditary spastic paraplegias (HSPs) represent a family of genetic disorders
comprising at least 72 different genes with the common pathology of progressive locomotor …
comprising at least 72 different genes with the common pathology of progressive locomotor …