Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the develo** and adult brain during homeostasis and …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …

There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Microglia are resident cells of the brain that regulate brain development, maintenance of
neuronal networks, and injury repair. Microglia serve as brain macrophages but are distinct …

Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's
disease, but their roles in disease have not been tested experimentally. We find that in …