Chemical fuels for molecular machinery

S Borsley, DA Leigh, BMW Roberts - Nature Chemistry, 2022 - nature.com
Chemical reaction networks that transform out-of-equilibrium 'fuel'to 'waste'are the engines
that power the biomolecular machinery of the cell. Inspired by such systems, autonomous …

From protein film electrochemistry to nanoconfined enzyme cascades and the electrochemical leaf

FA Armstrong, B Cheng, RA Herold… - Chemical …, 2022 - ACS Publications
Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

Arginine dependence of tumor cells: targeting a chink in cancer's armor

MD Patil, J Bhaumik, S Babykutty, UC Banerjee… - Oncogene, 2016 - nature.com
Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration

H Guak, S Al Habyan, EH Ma, H Aldossary… - Nature …, 2018 - nature.com
Dendritic cells (DCs) are first responders of the innate immune system that integrate signals
from external stimuli to direct context-specific immune responses. Current models suggest …

Sustained enzymatic activity and flow in crowded protein droplets

A Testa, M Dindo, AA Rebane, B Nasouri… - Nature …, 2021 - nature.com
Living cells harvest energy from their environments to drive the chemical processes that
enable life. We introduce a minimal system that operates at similar protein concentrations …

Nanozyme‐based artificial organelles: an emerging direction for artificial organelles

S Zhang, R Zhang, X Yan, K Fan - Small, 2022 - Wiley Online Library
Artificial organelles are compartmentalized nanoreactors, in which enzymes or enzyme‐
mimic catalysts exhibit cascade catalytic activities to mimic the functions of natural …

Nuclear metabolism and the regulation of the epigenome

R Boon, GG Silveira, R Mostoslavsky - Nature metabolism, 2020 - nature.com
Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …

The wisdom of crowds: regulating cell function through condensed states of living matter

S Alberti - Journal of cell science, 2017 - journals.biologists.com
Our understanding of cells has progressed rapidly in recent years, mainly because of
technological advances. Modern technology now allows us to observe molecular processes …

Spatiotemporal control for integrated catalysis

S Deng, BJ Jolly, JR Wilkes, Y Mu, JA Byers… - Nature Reviews …, 2023 - nature.com
Integrated catalysis is an emerging methodology that can streamline the multi-step synthesis
of complicated products in a single reaction vessel, achieving a high degree of control and …

[HTML][HTML] Organelle transporters and inter-organelle communication as drivers of metabolic regulation and cellular homeostasis

A Jain, R Zoncu - Molecular metabolism, 2022 - Elsevier
Background Spatial compartmentalization of metabolic pathways within membrane-
separated organelles is key to the ability of eukaryotic cells to precisely regulate their …