Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing Enterobacteriaceae
Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …
challenging, and some of the few active drugs are not available in many countries. For …
Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods
CR Lee, JH Lee, KS Park, YB Kim, BC Jeong… - Frontiers in …, 2016 - frontiersin.org
The emergence of carbapenem-resistant Gram-negative pathogens poses a serious threat
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …
to public health worldwide. In particular, the increasing prevalence of carbapenem-resistant …
The rapid spread of carbapenem-resistant Enterobacteriaceae
Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …
threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae …
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace
Acinetobacter baumannii is a common cause of serious nosocomial infections. Although
community-acquired infections are observed, the vast majority occur in people with …
community-acquired infections are observed, the vast majority occur in people with …
[HTML][HTML] Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli
Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …
Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?
The polymyxin antibiotics [colistin and polymyxin B (PMB)] are increasingly used as a last-
line option for the treatment of infections caused by extensively drug-resistant Gram …
line option for the treatment of infections caused by extensively drug-resistant Gram …
Recent advances and perspectives in the design and development of polymyxins
F Rabanal, Y Cajal - Natural product reports, 2017 - pubs.rsc.org
Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …
Colistin: still a lifesaver for the 21st century?
Introduction: Living in the 'era of antibiotic resistance'and facing the threat of an 'end to
antibiotics', physicians in the last decade have revived use of colistin, since the available …
antibiotics', physicians in the last decade have revived use of colistin, since the available …
Emerging Gram negative resistance to last-line antimicrobial agents fosfomycin, colistin and ceftazidime-avibactam–epidemiology, laboratory detection and treatment …
ABSTRACT Introduction: Multidrug-resistant (MDR) and extensively-drug-resistant (XDR)
Gram-negative bacteria have emerged as a major threat to human health globally. This has …
Gram-negative bacteria have emerged as a major threat to human health globally. This has …