[PDF][PDF] Protective alleles and precision healthcare in crewed spaceflight

LA Rutter, MJ MacKay, H Cope, NJ Szewczyk… - Nature …, 2024 - nature.com
Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing

TM Al-Turki, DG Maranon, CB Nelson… - Communications …, 2024 - nature.com
Telomeres are repetitive nucleoprotein complexes at chromosomal termini essential for
maintaining genome stability. Telomeric RNA, or TERRA, is a previously presumed long …

Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses

K Grigorev, TM Nelson, EG Overbey, N Houerbi… - Nature …, 2024 - nature.com
The advent of civilian spaceflight challenges scientists to precisely describe the effects of
spaceflight on human physiology, particularly at the molecular and cellular level. Newer …

NASA open science data repository: open science for life in space

SG Gebre, RT Scott, AM Saravia-Butler… - Nucleic Acids …, 2025 - academic.oup.com
Abstract Space biology and health data are critical for the success of deep space missions
and sustainable human presence off-world. At the core of effectively managing biomedical …

To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants

G Corti, JK Kim, FJ Enguita, JW Guarnieri… - Communications …, 2024 - nature.com
In the era of renewed space exploration, comprehending the effects of the space
environment on human health, particularly for deep space missions, is crucial. While …

Biological horizons: pioneering open science in the cosmos

SV Costes, CL Gentemann, SH Platts… - Nature …, 2024 - nature.com
With precious few spaceflight missions, all space-related biological and biomedical-health
data are priceless national resources that anyone should be able to easily access. The …

Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts' blood cells in space

M Moreno-Villanueva, LE Jimenez-Chavez… - Frontiers in …, 2025 - frontiersin.org
Introduction The impact of spaceflight on the immune system and mitochondria has been
investigated for decades. However, the molecular mechanisms underlying spaceflight …

Aging and putative frailty biomarkers are altered by spaceflight

A Camera, M Tabetah, V Castañeda, JK Kim… - Scientific Reports, 2024 - nature.com
Human space exploration poses inherent risks to astronauts' health, leading to molecular
changes that can significantly impact their well-being. These alterations encompass …

Advancing space medicine: a global perspective on in-orbit research and future directions

SG Chen, XP Chen, B Wu - Military Medical Research, 2025 - Springer
As humanity ventures deeper into space, our challenges become increasingly complex.
Space medicine, once confined to ensuring the health and safety of astronauts on low-Earth …