Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

The cytoskeleton of animal cells is one of the most complicated and functionally versatile
structures, involved in processes such as endocytosis, cell division, intra-cellular transport …

The vimentin gene (VIM) encodes one of the 71 human intermediate filament (IF) proteins,
which are the building blocks of highly ordered, dynamic, and cell type-specific fiber …

Cell movement has essential functions in development, immunity, and cancer. Various cell
migration patterns have been reported, but no general rule has emerged so far. Here, we …

Multiple attributes of the three-dimensional (3D) extracellular matrix (ECM) have been
independently implicated as regulators of cell motility, including pore size, crosslink density …

Living cells actively migrate in their environment to perform key biological functions—from
unicellular organisms looking for food to single cells such as fibroblasts, leukocytes or …

Eukaryotic cell movement is characterized by very diverse migration modes. Recent studies
show that cells can adapt to environmental cues, such as adhesion and geometric …

Many cell functions rely on the ability of microtubules to self-organize as complex networks.
In plants, cortical microtubules are essential to determine cell shape as they guide the …

Directional cell motility relies on the ability of single cells to establish a front-rear polarity and
can occur in the absence of external cues. The initiation of migration has often been …

For eukaryotic cells to heal wounds, respond to immune signals, or metastasize, they must
migrate, often by adhering to extracellular matrix (ECM). Cells may also deposit ECM …