Computational approaches to therapeutic antibody design: established methods and emerging trends
Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
Therapeutic monoclonal antibodies and their derivatives are key components of clinical
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
pipelines in the global biopharmaceutical industry. The availability of large datasets of …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease …
vaccines are highly effective at preventing infection and especially severe disease …
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Adjuvants are critical for improving the quality and magnitude of adaptive immune
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified …
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
efficacy in clinical trials, data on mRNA vaccine–induced immune responses are mostly …
Tissue adaptation and clonal segregation of human memory T cells in barrier sites
T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …
immunity and long-term protection. Here, we obtained blood and tissues from human organ …
Comprehensive map** of immune perturbations associated with severe COVID-19
L Kuri-Cervantes, MB Pampena, W Meng… - Science …, 2020 - science.org
Although critical illness has been associated with SARS-CoV-2–induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
The transcription factor T-bet resolves memory B cell subsets with distinct tissue distributions and antibody specificities in mice and humans
B cell subsets expressing the transcription factor T-bet are associated with humoral immune
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …
responses and autoimmunity. Here, we examined the anatomic distribution, clonal …
Modern hopfield networks and attention for immune repertoire classification
A central mechanism in machine learning is to identify, store, and recognize patterns. How to
learn, access, and retrieve such patterns is crucial in Hopfield networks and the more recent …
learn, access, and retrieve such patterns is crucial in Hopfield networks and the more recent …
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …