Abstract Purpose of Review Cryptosporidium spp.(C. hominis and C. parvum) are a major
cause of diarrhea-associated morbidity and mortality in young children globally. While C …

Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …

Diarrhoeal disease caused by Cryptosporidium is a major cause of morbidity and mortality in
young and malnourished children from low-and middle-income countries, with no vaccine or …

Early childhood cryptosporidiosis causes acute disease and mortality, as well as lasting
malnutrition and developmental delay. However, there are no safe and effective therapeutics …

Cryptosporidiosis is a leading cause of life-threatening diarrhea in young children in
resource-poor settings. To explore microbial influences on susceptibility, we screened 85 …

Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …

Parasitic diseases result in considerable human morbidity and mortality. The continuous
emergence and spread of new drug-resistant parasite strains is an obstacle to controlling …

Several lead compounds with potent activity in animal models and a favorable safety profile
have been identified. A sustained effort will be required to advance at least one to clinical …

Abstract Phosphatidylinositol 4-kinases (PI4Ks) could phosphorylate phosphatidylinositol
(PI) to produce phosphatidylinositol 4-phosphate (PI4P) and maintain its metabolic balance …

Despite several decades of research on therapeutics, cryptosporidiosis remains a major
concern for human and animal health. Even though this field of research to assess …