Collagen is a ubiquitous biomaterial in vertebrate animals. Although each of its 28 subtypes
contributes to the functions of many different tissues in the body, most studies on collagen or …

Osteogenesis imperfecta (OI) is a phenotypically and genetically heterogeneous skeletal
dysplasia characterized by bone fragility, growth deficiency, and skeletal deformity …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

The extracellular matrix (ECM) is synthesized and secreted by embryonic cells beginning at
the earliest stages of development. Our understanding of ECM composition, structure and …

The collagen superfamily of proteins now contains at least 19 proteins formally defined as
collagens and an additional ten proteins that have collagen-like domains. The most …

The structure of a protein triple helix has been determined at 1.9 angstrom resolution by x-
ray crystallographic studies of a collagen-like peptide containing a single substitution of the …

Carbonic anhydrases (CAs I-VII) are products of a gene family that encodes seven isozymes
and several homologous, CA-related proteins. All seven isozymes have been cloned …

Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by
fragile bones and easy susceptibility to fracture. Most cases of OI are caused by mutations in …

Background: The collagen triple helix is a unique protein motif defined by the supercoiling of
three polypeptide chains in a polyproline II conformation. It is a major domain of all collagen …

Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major
component of the cornea, dermal, and muscle connective tissues. Mice homozygous for a …