Epigenetic therapies targeting histone lysine methylation: complex mechanisms and clinical challenges
S Gold, A Shilatifard - The Journal of Clinical Investigation, 2024 - jci.org
As epigenetic therapies continue to gain ground as potential treatment strategies for cancer
and other diseases, compounds that target histone lysine methylation and the enzyme …
and other diseases, compounds that target histone lysine methylation and the enzyme …
[HTML][HTML] Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules
Polycomb proteins are a fundamental repressive system that plays crucial developmental
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
roles by orchestrating cell-type-specific transcription programs that govern cell identity …
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic …
KH Gretarsson, S Abini-Agbomson, SL Gloor… - Science …, 2024 - science.org
During tumor development, promoter CpG islands that are normally silenced by Polycomb
repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by …
repressive complexes (PRCs) become DNA-hypermethylated. The molecular mechanism by …
Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation
of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well …
of histone modifications. Histone H2AK119 monoubiquitination (H2AK119Ub), a well …
Nucleosome conformation dictates the histone code
MR Marunde, HA Fuchs, JM Burg, IK Popova, A Vaidya… - Elife, 2024 - elifesciences.org
Histone post-translational modifications (PTMs) play a critical role in chromatin regulation. It
has been proposed that these PTMs form localized 'codes' that are read by specialized …
has been proposed that these PTMs form localized 'codes' that are read by specialized …
Beyond the tail: the consequence of context in histone post-translational modification and chromatin research
EN Weinzapfel, KN Fedder-Semmes… - Biochemical …, 2024 - portlandpress.com
The role of histone post-translational modifications (PTMs) in chromatin structure and
genome function has been the subject of intense debate for more than 60 years. Though …
genome function has been the subject of intense debate for more than 60 years. Though …
Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1
VG López, MI Valencia-Sánchez, S Abini-Agbomson… - Nature, 2024 - nature.com
Epigenetic inheritance of silent chromatin domains is fundamental to cellular memory during
embryogenesis, but it must overcome the dilution of repressive histone modifications during …
embryogenesis, but it must overcome the dilution of repressive histone modifications during …
[HTML][HTML] DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability
BM Foster, Z Wang, CK Schmidt - Biochemical Journal, 2024 - portlandpress.com
Maintaining stability of the genome requires dedicated DNA repair and signalling processes
that are essential for the faithful duplication and propagation of chromosomes. These DNA …
that are essential for the faithful duplication and propagation of chromosomes. These DNA …
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes
Chromatin regulators alter the physical properties of chromatin to make it more or less
permissive to transcription by modulating another protein's access to a specific DNA …
permissive to transcription by modulating another protein's access to a specific DNA …
A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia
Z Dong, H Sepulveda, LJ Arteaga-Vazquez… - Proceedings of the …, 2025 - pnas.org
ASXL transcriptional regulator 1 (ASXL1) is one of the three most frequently mutated genes
in age-related clonal hematopoiesis (CH), alongside DNA methyltransferase 3 alpha …
in age-related clonal hematopoiesis (CH), alongside DNA methyltransferase 3 alpha …