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Transplantable Tissue—Immune and Genome Engineering Dramatic advancements in the
use of synthetic and mechanical devices to replace tissues have been made, but restoring …

Pig organs may offer a solution to the shortage of human donor organs for transplantation,
but concerns remain about possible cross-species transmission of porcine endogenous …

The vasopressor angiotensin II regulates vascular contractility and blood pressure through
binding to type 1 angiotensin II receptors (AT1; refs,). Bradykinin, a vasodepressor, is a …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Recent interest in the use of porcine organs, tissues, and cells for xenotransplantation to
humans has highlighted the need to characterize the properties of pig endogenous …

Xenotransplantation may be a solution to overcome the shortage of organs for the treatment
of patients with organ failure, but it may be associated with the transmission of porcine …

Animal donors such as pigs could provide an alternative source of organs for
transplantation. However, the promise of xenotransplantation is offset by the possible public …

Background The study of whether porcine xenografts can lead to porcine endogenous
retrovirus (PERV) infection of recipients is critical for evaluating the safety of pig-to-man …

Hurdles exist to clinical xenotransplantation including potential infectious transmission from
nonhuman species to xenograft recipients. In anticipation of clinical trials of …