International Union of Basic and Clinical Pharmacology. CVI: GABAA receptor subtype-and function-selective ligands: key issues in translation to humans
GABA A receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …
Remote control of neuronal signaling
A significant challenge for neuroscientists is to determine how both electrical and chemical
signals affect the activity of cells and circuits and how the nervous system subsequently …
signals affect the activity of cells and circuits and how the nervous system subsequently …
Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons
P Wulff, AA Ponomarenko, M Bartos… - Proceedings of the …, 2009 - National Acad Sciences
Hippocampal theta (5–10 Hz) and gamma (35–85 Hz) oscillations depend on an inhibitory
network of GABAergic interneurons. However, the lack of methods for direct and cell-type …
network of GABAergic interneurons. However, the lack of methods for direct and cell-type …
Postnatal differentiation of basket cells from slow to fast signaling devices
D Doischer, JA Hosp, Y Yanagawa… - Journal of …, 2008 - Soc Neuroscience
Gamma frequency (30–100 Hz) oscillations in the mature cortex underlie higher cognitive
functions. Fast signaling in GABAergic interneuron networks plays a key role in the …
functions. Fast signaling in GABAergic interneuron networks plays a key role in the …
How can drug discovery for psychiatric disorders be improved?
Y Agid, G Buzsáki, DM Diamond… - Nature reviews Drug …, 2007 - nature.com
Psychiatric disorders such as depression, anxiety and schizophrenia are leading causes of
disability worldwide, and have a huge societal impact. However, despite the clear need for …
disability worldwide, and have a huge societal impact. However, despite the clear need for …
Endozepines and their receptors: structure, functions and pathophysiological significance
The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …
the search for endogenous BZ receptor ligands designated by the generic term …
Acyl coenzyme A binding protein (ACBP): An aging‐and disease‐relevant “autophagy checkpoint”
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …
GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep–wake switch or propofol-induced loss of consciousness
The activity of histaminergic neurons in the tuberomammillary nucleus (TMN) of the
hypothalamus correlates with an animal's behavioral state and maintains arousal. We …
hypothalamus correlates with an animal's behavioral state and maintains arousal. We …
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
P Wulff, T Goetz, E Leppä, AM Linden, M Renzi… - Nature …, 2007 - nature.com
In mammals, identifying the contribution of specific neurons or networks to behavior is a key
challenge. Here we describe an approach that facilitates this process by enabling the rapid …
challenge. Here we describe an approach that facilitates this process by enabling the rapid …
Benzodiazepines compromise the outcome of cancer immunotherapy
Acyl CoA binding protein (ACBP, which is encoded by diazepam binding inhibitor, DBI) acts
on the gamma-amino butyric acid (GABA) receptor type A via a specific binding site that is …
on the gamma-amino butyric acid (GABA) receptor type A via a specific binding site that is …