Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Background Cardiovascular disease is a major cause of excess mortality in people with
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …

Phenome-wide association study (PheWAS) has been increasingly used to identify novel
genetic associations across a wide spectrum of phenotypes. This systematic review aims to …

Congenital heart diseases often involve maldevelopment of the evolutionarily recent right
heart chamber. To gain insight into right heart structure and function, we fine-tuned deep …

Cardiac blood flow is a critical determinant of human health. However, the definition of its
genetic architecture is limited by the technical challenge of capturing dynamic flow volumes …

Background The left ventricular outflow tract (LVOT) and ascending aorta are spatially
complex, with distinct pathologies and embryologic origins. Prior work examined the …

The fibrous annulus of the mitral valve plays an important role in valvular function and
cardiac physiology, while normal variation in the size of cardiovascular anatomy may share …

Background Congenital heart defects (CHD) are structural defects of the heart affecting
approximately 1% of newborns. They exhibit low penetrance and non-Mendelian patterns of …

Abstract Purpose of Review Increases in the availability of genetic data and advances in the
tools and methods for their analyses have enabled well-powered genetic association …

Background: A large proportion of genetic risk remains unexplained for structural heart
disease involving the interventricular septum (IVS) including hypertrophic cardiomyopathy …