Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

Estrogen, estrogen receptor and lung cancer

LH Hsu, NM Chu, SH Kao - International journal of molecular sciences, 2017 - mdpi.com
Estrogen has been postulated as a contributor for lung cancer development and
progression. We reviewed the current knowledge about the expression and prognostic …

G protein‐coupled estrogen receptor‐selective ligands modulate endometrial tumor growth

WK Petrie, MK Dennis, C Hu, D Dai… - Obstetrics and …, 2013 - Wiley Online Library
Endometrial carcinoma is the most common cancer of the female reproductive tract.
GPER/GPR30 is a 7‐transmembrane spanning G protein‐coupled receptor that has been …

Influence of estrogen on the NSCLC microenvironment: a comprehensive picture and clinical implications

T Smida, TC Bruno, LP Stabile - Frontiers in Oncology, 2020 - frontiersin.org
Lung cancer mortality represents the leading cause of cancer related deaths in the United
States and worldwide. Almost half of these deaths occur in female patients, making lung …

Sex hormones and lung inflammation

J Reyes-Garcia, LM Montano… - Lung Inflammation in …, 2021 - Springer
Inflammation is a characteristic marker in numerous lung disorders. Several immune cells,
such as macrophages, dendritic cells, eosinophils, as well as T and B lymphocytes …

[HTML][HTML] GPER-novel membrane estrogen receptor

MA Zimmerman, RA Budish, S Kashyap… - Clinical science …, 2016 - ncbi.nlm.nih.gov
The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …

Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway

KS Zhang, HQ Chen, YS Chen, KF Qiu… - Biomedicine & …, 2014 - Elsevier
Lung cancer is one of the leading causes of cancer deaths worldwide. Recent evidences
indicated that bisphenol A (BPA), a wide contaminant with endocrine disrupting activity …

GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast

AL Scaling, ER Prossnitz, HJ Hathaway - Hormones and Cancer, 2014 - Springer
Abstract 17β-Estradiol (estrogen), through receptor binding and activation, is required for
mammary gland development. Estrogen stimulates epithelial proliferation in the mammary …

Environmental estrogens and their biological effects through GPER mediated signal pathways

Y Qie, W Qin, K Zhao, C Liu, L Zhao, LH Guo - Environmental Pollution, 2021 - Elsevier
Many environmental chemicals have been found to exert estrogenic effects in cells and
experimental animals by activating nuclear receptors such as estrogen receptors and …

Estrogenic steroid hormones in lung cancer

JM Siegfried, LP Stabile - Seminars in oncology, 2014 - Elsevier
It is becoming increasingly clear that steroid hormones are involved in the biology of many
organs outside the reproductive system. Evidence has been accumulating since the mid …