Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic
alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; …

EMT and MET comprise the processes by which cells transit between epithelial and
mesenchymal states, and they play integral roles in both normal development and cancer …

Chronic inflammation, regardless of infectious agents, plays important roles in the
development of various cancers, particularly in digestive organs, including Helicobacter …

Breast cancer affects one in seven women worldwide during their lifetime. Widespread
mammographic screening programs and education campaigns allow for early detection of …

Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

Abstract Background Enadenotucirev (formerly ColoAd1) is a tumor-selective chimeric
adenovirus with demonstrated preclinical activity. This phase 1 Mechanism of Action study …

There always exists a field with genetically altered cells with a high risk of develo**
premalignant and malignant lesions. It may often happen that an individual stem cell is …

It was recently shown that a large portion of the human transcriptome can originate from
within repetitive elements, leading to ectopic expression of protein-coding genes. However …

The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially
transform a cell, or a group of cells in a particular organ. The early genetic events might lead …