Designing of gradient scaffolds and their applications in tissue regeneration
A Pattnaik, AS Sanket, S Pradhan, R Sahoo, S Das… - Biomaterials, 2023 - Elsevier
Gradient scaffolds are isotropic/anisotropic three-dimensional structures with gradual
transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular …
transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular …
Principles, mechanisms and functions of entrainment in biological oscillators
A Jiménez, Y Lu, A Jambhekar… - Interface Focus, 2022 - royalsocietypublishing.org
Entrainment is a phenomenon in which two oscillators interact with each other, typically
through physical or chemical means, to synchronize their oscillations. This phenomenon …
through physical or chemical means, to synchronize their oscillations. This phenomenon …
Genetics of sinoatrial node function and heart rate disorders
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …
electrical activation and ensuring that the heart's functional cardiac output meets …
Hippo-yap signaling maintains sinoatrial node homeostasis
Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating
rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood …
rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood …
A single cell transcriptional roadmap of human pacemaker cell differentiation
A Wiesinger, J Li, L Fokkert, P Bakker, AO Verkerk… - Elife, 2022 - elifesciences.org
Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the
heart. Studies in animal models have revealed that pacemaker cells share a common …
heart. Studies in animal models have revealed that pacemaker cells share a common …
Characterization of the pace-and-drive capacity of the human sinoatrial node: A 3D in silico study
The sinoatrial node (SAN) is a complex structure that spontaneously depolarizes
rhythmically (" pacing") and excites the surrounding non-automatic cardiac cells (" drive") to …
rhythmically (" pacing") and excites the surrounding non-automatic cardiac cells (" drive") to …
Emergent activity, heterogeneity, and robustness in a calcium feedback model of the sinoatrial node
The sinoatrial node (SAN) is the primary pacemaker of the heart. SAN activity emerges at an
early point in life and maintains a steady rhythm for the lifetime of the organism. The ion …
early point in life and maintains a steady rhythm for the lifetime of the organism. The ion …
High cardiomyocyte diversity in human early prenatal heart development
C Sylvén, E Wärdell, A Månsson-Broberg, E Cingolani… - Iscience, 2023 - cell.com
Cardiomyocytes play key roles during cardiogenesis, but have poorly understood features,
especially in prenatal stages. Here, we characterized human prenatal cardiomyocytes, 6.5 …
especially in prenatal stages. Here, we characterized human prenatal cardiomyocytes, 6.5 …
Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications
H Rayat Pisheh, A Darvishi… - … in Bioengineering and …, 2024 - frontiersin.org
Cardiovascular diseases represent one of the leading causes of death worldwide. Despite
significant advances in the diagnosis and treatment of these diseases, numerous challenges …
significant advances in the diagnosis and treatment of these diseases, numerous challenges …
The virtual sinoatrial node: What did computational models tell us about cardiac pacemaking?
Since its discovery, the sinoatrial node (SAN) has represented a fascinating and complex
matter of research. Despite over a century of discoveries, a full comprehension of …
matter of research. Despite over a century of discoveries, a full comprehension of …