What Is New in the Anti–Pseudomonas aeruginosa Clinical Development Pipeline Since the 2017 WHO Alert?

S Reig, A Le Gouellec, S Bleves - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and
mortality worldwide. Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are …

Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis

RB Singh, S Das, J Chodosh, N Sharma… - Progress in Retinal and …, 2022 - Elsevier
Bacterial keratitis continues to be one of the leading causes of corneal blindness in the
developed as well as the develo** world, despite swift progress since the dawn of the …

Multienzyme‐Like Nanozyme Encapsulated Ocular Microneedles for Keratitis Treatment

S Liu, Q Bai, Y Jiang, Y Gao, Z Chen, L Shang… - Small, 2024 - Wiley Online Library
Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one of the
leading causes of severe visual disability and blindness. Keratitis treatment requires both …

Determination of probability of causative pathogen in infectious keratitis using deep learning algorithm of slit-lamp images

A Koyama, D Miyazaki, Y Nakagawa, Y Ayatsuka… - Scientific reports, 2021 - nature.com
Corneal opacities are important causes of blindness, and their major etiology is infectious
keratitis. Slit-lamp examinations are commonly used to determine the causative pathogen; …

[HTML][HTML] Pivotal role of corneal fibroblasts in progression to corneal ulcer in bacterial keratitis

T Nishida, K Sugioka, K Fukuda… - International Journal of …, 2021 - mdpi.com
The shape and transparency of the cornea are essential for clear vision. However, its
location at the ocular surface renders the cornea vulnerable to pathogenic microorganisms …

Neutrophil extracellular traps and their possible implications in ocular herpes infection

D Kapoor, D Shukla - Pathogens, 2023 - mdpi.com
Neutrophil extracellular traps (NETs) are net-like structures released from neutrophils. NETs
predominantly contain cell-free deoxyribonucleic acid (DNA) decorated with histones and …

Comparison of 16S rDNA amplicon sequencing with the culture method for diagnosing causative pathogens in bacterial corneal infections

N An, C Wang, X Dou, X Liu, J Wu… - … vision science & …, 2022 - tvst.arvojournals.org
Purpose: The purpose of this study was to explore if 16S rDNA amplicon sequencing can
improve the conventional diagnosis of causative pathogens for bacterial corneal infection …

[HTML][HTML] Neutrophil extracellular traps (NETs) in ocular diseases: an update

J Zeng, M Wu, Y Zhou, M Zhu, X Liu - Biomolecules, 2022 - mdpi.com
Neutrophil extracellular traps (NETs) are net-like complexes expelled from neutrophils,
composing cell-free deoxyribonucleic acid (DNA), histones, and neutrophil granule proteins …

POSS and PEG Contained Copolymer for Antibioadhesive Rigid Contact Lenses Materials Application

L Liang, Y Hu, Y Hong, Z Wu, H Chen, Q Lin - Biomacromolecules, 2024 - ACS Publications
Myopia is a global public health issue. Rigid contact lenses (RCLs) are an effective way to
correct or control myopia. However, bioadhesion issues remain one of the significant …

Vision redemption: Self-reporting AIEgens for combined treatment of bacterial keratitis

C Peng, W Sun, C Zhou, S Qiang, M Jiang, JWY Lam… - Biomaterials, 2021 - Elsevier
Bacterial keratitis (BK) is one of the most commonly leading causes of visual impairment and
blindness worldwide, and suffers the risk of drug-resistant infections due to the abuse of …