Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively develo** cardiomyopathy. Doxorubicin is one of the most highly prescribed …

Doxorubicin (DOX) is the most widely used anthracycline anticancer agent; however, its
cardiotoxicity limits its clinical efficacy. Numerous studies have elucidated the mechanisms …

Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate
energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the …

Doxorubicin (DOX) is an anticancer anthracycline that presents a dose‐dependent and
cumulative cardiotoxicity as one of the most serious side effects. Several hypotheses have …

The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

Doxorubicin (DOX) is a chemotherapeutic agent effective in the treatment of many cancers.
However, cardiac dysfunction caused by DOX limits its clinical use. DOX is believed to be …

Background Modern lifestyles, especially high-caloric intake and physical inactivity,
contribute to the increased prevalence of non-alcoholic fatty liver disease (NAFLD), which …

Anthracycline-containing chemotherapy (eg, doxorubi-cin) is well known to cause dose-
dependent, progressive cardiac damage clinically manifest as decreased left ventricular …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Doxorubicin (DOX) is one of the most effective cytotoxic anticancer drugs used for the
treatment of hematological malignancies, as well as a broad range of solid tumors. However …