Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Strain improvement of Trichoderma harzianum for enhanced biocontrol capacity: Strategies and prospects

Z **ao, Q Zhao, W Li, L Gao, G Liu - Frontiers in microbiology, 2023 - frontiersin.org
In the control of plant diseases, biocontrol has the advantages of being efficient and safe for
human health and the environment. The filamentous fungus Trichoderma harzianum and its …

Polystyrene upcycling into fungal natural products and a biocontrol agent

C Rabot, Y Chen, SY Lin, B Miller… - Journal of the …, 2023 - ACS Publications
Polystyrene (PS) is one of the most used yet infrequently recycled plastics. Although
manufactured on the scale of 300 million tons per year globally, current approaches toward …

Transcriptional activation of biosynthetic gene clusters in filamentous fungi

L Mózsik, R Iacovelli, RAL Bovenberg… - … in Bioengineering and …, 2022 - frontiersin.org
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …

Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans

YM Chiang, TS Lin, CCC Wang - Journal of natural products, 2022 - ACS Publications
Fungal natural products comprise a wide range of bioactive compounds including important
drugs and agrochemicals. Intriguingly, bioinformatic analyses of fungal genomes have …

Anthraquinone-fused enediynes: discovery, biosynthesis and development

X Yan - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to the end of July, 2021 Anthraquinone-fused enediynes (AFEs) are a
subfamily of enediyne natural products. Dynemicin A (DYN A), the first member of the AFE …

A genetic tool to express long fungal biosynthetic genes

L Kirchgaessner, JM Wurlitzer, PS Seibold… - Fungal Biology and …, 2023 - Springer
Abstract Background Secondary metabolites (SMs) from mushroom-forming fungi
(Basidiomycota) and early diverging fungi (EDF) such as Mucoromycota are scarcely …

Biosynthesis of Viridicatol in Penicillium palitans Implies a Cytochrome P450-Mediated meta Hydroxylation at a Monoalkylated Benzene Ring

ZX Zhang, ZH Li, WB Yin, SM Li - Organic Letters, 2021 - ACS Publications
Cyclopenol (1) and viridicatol (6) with m-hydroxyl groups were isolated from a culture of
Penicillium palitans. Genome mining and heterologous expression in Aspergillus nidulans …

Chemical structures, biological activities, and biosynthetic analysis of secondary metabolites of the Diatrypaceae family: A comprehensive review

SJ Kang, L Zhao, H Wang, JM Gao, J Qi - Mycology, 2024 - Taylor & Francis
The family Diatrypaceae is a less well-known group within the order Xylariales
(Ascomycota). Initially, the focus on its metabolites was related to the pathogenicity of one of …

Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans

Y Yao, EL Yang, Y Pan, X Shu, G Liu - Applied Microbiology and …, 2023 - Springer
Physcion is one of natural anthraquinones, registered as a novel plant-derived fungicide
due to its excellent prevention of plant disease. However, the current production of physcion …