[HTML][HTML] Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

S Wang, SL Friedman - Science translational medicine, 2023 - science.org
Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Pathophysiological mechanisms of liver injury in COVID‐19

AD Nardo, M Schneeweiss‐Gleixner… - Liver …, 2021 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute
Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide …

Mechanisms of fibrosis development in nonalcoholic steatohepatitis

RF Schwabe, I Tabas, UB Pajvani - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …

Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion

Y Minami, A Hoshino, Y Higuchi, M Hamaguchi… - Nature …, 2023 - nature.com
Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …

[PDF][PDF] Single‐cell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice

WU Yang, H He, T Wang, N Su, F Zhang, K Jiang… - …, 2021 - Wiley Online Library
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

UCP1 governs liver extracellular succinate and inflammatory pathogenesis

EL Mills, C Harmon, MP Jedrychowski, H **ao… - Nature …, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is
intimately linked with obesity and type 2 diabetes. Liver inflammation is a hallmark of NAFLD …

Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

TM Savage, KT Fortson, K de Los Santos-Alexis… - Immunity, 2024 - cell.com
Production of amphiregulin (Areg) by regulatory T (Treg) cells promotes repair after acute
tissue injury. Here, we examined the function of Treg cells in non-alcoholic steatohepatitis …

[HTML][HTML] Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): A concise review

N Nasiri-Ansari, T Androutsakos, CM Flessa, I Kyrou… - Cells, 2022 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

ZY Wang, A Keogh, A Waldt, R Cuttat, M Neri, S Zhu… - Scientific reports, 2021 - nature.com
Fibrosis is characterized by the excessive production of collagen and other extracellular
matrix (ECM) components and represents a leading cause of morbidity and mortality …