Many clonal organisms experience occasional events of sexual recombination, with
profound consequences for their population dynamics and evolutionary trajectories. With the …

The genomic plasticity of Candida albicans, a commensal and common opportunistic fungal
pathogen, continues to reveal unexpected surprises. Once thought to be asexual, we now …

Candida species are the most common cause of opportunistic fungal infection worldwide.
Here we report the genome sequences of six Candida species and compare these and …

Candida albicans is both a member of the healthy human microbiome and a major pathogen
in immunocompromised individuals. Infections are typically treated with azole inhibitors of …

Candida albicans has an elaborate, yet efficient, mating system that promotes conjugation
between diploid a and α strains. The product of mating is a tetraploid a/α cell that must …

Acquired azole resistance is a serious clinical problem that is often associated with the
appearance of aneuploidy and, in particular, with the formation of an isochromosome [i (5L)] …

The mechanisms and rates by which genotypic and phenotypic variation is generated in
opportunistic, eukaryotic pathogens during growth in hosts are not well understood. We …

Candida albicans, a diploid yeast commensal and opportunist pathogen, has evolved
unusual mechanisms for maintenance of genetic diversity in the absence of a complete …

Candida albicans is a human commensal that is also responsible for superficial and
systemic infections. Little is known about the carriage of C. albicans in the digestive tract and …

In vitro studies suggest that stress may generate random standing variation and that different
cellular and ploidy states may evolve more rapidly under stress. Yet this idea has not been …