[HTML][HTML] Epigenomic Reprogramming in Gout
Gout is a crystal-induced arthropathy in which monosodium urate (MSU) crystals precipitate
within joints as a result of persistent hyperuricemia and elicit an inflammatory response. An …
within joints as a result of persistent hyperuricemia and elicit an inflammatory response. An …
Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls
Objectives Gout is caused by the response of the innate immune system to monosodium
urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a …
urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a …
Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease
Objective The genetic basis of calcium pyrophosphate deposition (CPPD) disease is largely
unknown. This limits the development of therapeutic strategies. We aimed to analyze a …
unknown. This limits the development of therapeutic strategies. We aimed to analyze a …