Technology of deep brain stimulation: current status and future directions

JK Krauss, N Lipsman, T Aziz, A Boutet… - Nature Reviews …, 2021 - nature.com
Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based
neuromodulation. DBS is a standard of care in Parkinson disease, essential tremor and …

Past, present, and future of deep brain stimulation: hardware, software, imaging, physiology and novel approaches

J Frey, J Cagle, KA Johnson, JK Wong… - Frontiers in …, 2022 - frontiersin.org
Deep brain stimulation (DBS) has advanced treatment options for a variety of neurologic and
neuropsychiatric conditions. As the technology for DBS continues to progress, treatment …

[HTML][HTML] Lead-DBS v3. 0: Map** deep brain stimulation effects to local anatomy and global networks

C Neudorfer, K Butenko, S Oxenford, N Rajamani… - Neuroimage, 2023 - Elsevier
Following its introduction in 2014 and with support of a broad international community, the
open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform …

A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

N Li, JC Baldermann, A Kibleur, S Treu… - Nature …, 2020 - nature.com
Multiple surgical targets for treating obsessive-compulsive disorder with deep brain
stimulation (DBS) have been proposed. However, different targets may modulate the same …

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

A Horn, MM Reich, S Ewert, N Li… - Proceedings of the …, 2022 - National Acad Sciences
Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …

Probabilistic map** of deep brain stimulation: insights from 15 years of therapy

GJB Elias, A Boutet, SE Joel, J Germann… - Annals of …, 2021 - Wiley Online Library
Deep brain stimulation (DBS) depends on precise delivery of electrical current to target
tissues. However, the specific brain structures responsible for best outcome are still debated …

Non-motor outcomes depend on location of neurostimulation in Parkinson's disease

JN Petry-Schmelzer, M Krause, TA Dembek, A Horn… - Brain, 2019 - academic.oup.com
Deep brain stimulation of the subthalamic nucleus is an effective and established therapy for
patients with advanced Parkinson's disease improving quality of life, motor symptoms and …

Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease

A Horn, G Wenzel, F Irmen, J Huebl, N Li, WJ Neumann… - Brain, 2019 - academic.oup.com
Neuroimaging has seen a paradigm shift away from a formal description of local activity
patterns towards studying distributed brain networks. The recently defined framework of the …

[HTML][HTML] Normative vs. patient-specific brain connectivity in deep brain stimulation

Q Wang, H Akram, M Muthuraman… - Neuroimage, 2021 - Elsevier
Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have
emerged as informative tools to estimate outcome variability across DBS patients. Given the …

Map** dysfunctional circuits in the frontal cortex using deep brain stimulation

B Hollunder, JL Ostrem, IA Sahin, N Rajamani… - Nature …, 2024 - nature.com
Frontal circuits play a critical role in motor, cognitive and affective processing, and their
dysfunction may result in a variety of brain disorders. However, exactly which frontal …