Unlike other CDKs, CDK9 does not regulate the cell cycle but promotes RNA synthesis in
genetic programmes for cell growth, differentiation and viral pathogenesis. It is becoming …

No safe and effective cure currently exists for human immunodeficiency virus (HIV).
However, antiretroviral therapy can prolong the lives of HIV patients and lowers the …

We report the synthesis and biological characterization of 3-(pyrimidin-4-yl)-7-azaindoles
(meriolins), a chemical hybrid between the natural products meridianins and variolins …

Many microRNAs (miRNAs) are encoded within the introns of RNA Pol II transcripts, often as
polycistronic precursors. Here, we demonstrate the optimization of an intron encoding three …

Pharmacological inhibitors of cyclin-dependent kinases (CDKs) have a wide therapeutic
potential. Among the CDK inhibitors currently under clinical trials, the 2, 6, 9-trisubstituted …

The human immunodeficiency virus type 1 (HIV-1) Tat is a 14-kDa viral protein that acts as a
potent transactivator by binding to the transactivation-responsive region, a structured RNA …

Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) was identified earlier as an
inhibitor of positive transcription elongation factor b (P-TEFb), which is a key transcriptional …

Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is an inhibitor of positive
transcription elongation factor b (P-TEFb) that has recently been shown to be involved in …

After entry into the target cell, the human immunodeficiency virus type I (HIV) integrates into
the host genome and becomes a proviral eukaryotic transcriptional unit. Transcriptional …

Despite efficient antiretroviral therapy, eradication of HIV-1 infection is challenging and
requires novel biological insights and therapeutic strategies. Among other physiological and …