Lipidomics from sample preparation to data analysis: a primer

T Züllig, M Trötzmüller, HC Köfeler - Analytical and bioanalytical chemistry, 2020 - Springer
Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

[HTML][HTML] Machine learning applications for mass spectrometry-based metabolomics

UW Liebal, ANT Phan, M Sudhakar, K Raman… - Metabolites, 2020 - mdpi.com
The metabolome of an organism depends on environmental factors and intracellular
regulation and provides information about the physiological conditions. Metabolomics helps …

A metabolome atlas of the aging mouse brain

J Ding, J Ji, Z Rabow, T Shen, J Folz… - Nature …, 2021 - nature.com
The mammalian brain relies on neurochemistry to fulfill its functions. Yet, the complexity of
the brain metabolome and its changes during diseases or aging remain poorly understood …

Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models

L Su, Y Chen, C Huang, S Wu, XJ Wang… - Science translational …, 2023 - science.org
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell
apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways …

Taking the leap between analytical chemistry and artificial intelligence: A tutorial review

LB Ayres, FJV Gomez, JR Linton, MF Silva… - Analytica Chimica …, 2021 - Elsevier
The last 10 years have witnessed the growth of artificial intelligence into different research
areas, emerging as a vibrant discipline with the capacity to process large amounts of …

High resolution mass spectrometry in lipidomics

T Züllig, HC Köfeler - Mass spectrometry reviews, 2021 - Wiley Online Library
The boost of research output in lipidomics during the last decade is tightly linked to improved
instrumentation in mass spectrometry. Associated with this trend is the shift from low …

Metabolomics study of COVID-19 patients in four different clinical stages

A Valdés, LO Moreno, SR Rello, A Orduña… - Scientific reports, 2022 - nature.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus
strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To …

Recurrent topics in mass spectrometry-based metabolomics and lipidomics—standardization, coverage, and throughput

E Rampler, YE Abiead, H Schoeny, M Rusz… - Analytical …, 2020 - ACS Publications
We have come a long way in the last years of develo** analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

High-resolution mass spectrometry for human exposomics: Expanding chemical space coverage

Y Lai, JP Koelmel, DI Walker, EJ Price… - Environmental …, 2024 - ACS Publications
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

Artificial intelligence in metabolomics: A current review

J Chi, J Shu, M Li, R Mudappathi, Y **, F Lewis… - TrAC Trends in …, 2024 - Elsevier
Metabolomics and artificial intelligence (AI) form a synergistic partnership. Metabolomics
generates large datasets comprising hundreds to thousands of metabolites with complex …