As the adult mammalian heart has limited potential for regeneration and repair, the loss of
cardiomyocytes during injury and disease can result in heart failure and death. The cellular …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Development of the human intestine is not well understood. Here, we link single-cell RNA
sequencing and spatial transcriptomics to characterize intestinal morphogenesis through …

Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …

Numerous physiological and pathological stimuli promote the rearrangement of the actin
cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively …

Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of
cardiac transcription factors or microRNAs has recently been demonstrated. The potential …

The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the
pathogenesis of a variety of proliferative vascular diseases. Recently, we have found that …

Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells
(SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator …

Background—Smooth muscle cells (SMCs) are remarkably plastic. Their reversible
differentiation is required for growth and wound healing but also contributes to pathologies …