[HTML][HTML] The urgent need to recover MHC class I in cancers for effective immunotherapy
Highlights•Tumor immune escape compromises the efficacy of cancer immunotherapy.•Loss
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
MHC class I antigens, immune surveillance, and tumor immune escape
A Garcia‐Lora, I Algarra… - Journal of cellular …, 2003 - Wiley Online Library
Oncogenic transformation in human and experimental animals is not necessarily followed by
the appearance of a tumor mass. The immune system of the host can recognize tumor …
the appearance of a tumor mass. The immune system of the host can recognize tumor …
Histone demethylase KDM5D upregulation drives sex differences in colon cancer
Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the
molecular and genetic bases of such sex differences are ill-defined and presumptively …
molecular and genetic bases of such sex differences are ill-defined and presumptively …
Loss of mismatched HLA in leukemia after stem-cell transplantation
L Vago, SK Perna, M Zanussi, B Mazzi… - … England Journal of …, 2009 - Mass Medical Soc
Background Transplantation of hematopoietic stem cells from partially matched family
donors is a promising therapy for patients who have a hematologic cancer and are at high …
donors is a promising therapy for patients who have a hematologic cancer and are at high …
The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens
Human peripheral blood lymphocytes can be transduced to express antigen-dependent
CD3ζ chimeric immune receptors (CIRs), which function independently of the T-cell receptor …
CD3ζ chimeric immune receptors (CIRs), which function independently of the T-cell receptor …
“Hard” and “soft” lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy
The ability of cancer cells to escape from the natural or immunotherapy‐induced antitumor
immune response is often associated with alterations in the tumor cell surface expression of …
immune response is often associated with alterations in the tumor cell surface expression of …
Rejection versus escape: the tumor MHC dilemma
Most tumor cells derive from MHC-I-positive normal counterparts and remain positive at
early stages of tumor development. T lymphocytes can infiltrate tumor tissue, recognize and …
early stages of tumor development. T lymphocytes can infiltrate tumor tissue, recognize and …
The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape
Tumor immune escape variants can be identified in human and experimental tumors. A
variety of different strategies are used by tumor cells to avoid recognition by different …
variety of different strategies are used by tumor cells to avoid recognition by different …
The challenges of HLA class I loss in cancer immunotherapy: facts and hopes
HLA class I molecules are key in tumor recognition and T cell–mediated elimination. Loss of
tumor HLA class I expression with different underlying molecular defects results in reduced …
tumor HLA class I expression with different underlying molecular defects results in reduced …
Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma
C Ritter, K Fan, A Paschen, S Reker Hardrup… - Scientific reports, 2017 - nature.com
Merkel cell carcinoma (MCC) is a rare and aggressive, yet highly immunogenic skin cancer.
The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC …
The latter is due to its viral or UV-associated carcinogenesis. For tumor progression MCC …