An appropriate diagnostic evaluation is essential for the most appropriate treatment to be
performed. Currently, macroprolactinemia is the third most frequent cause of …

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and
they represent an important cause of hypogonadism and infertility in both sexes. The …

In June 2005, an ad hoc Expert Committee formed by the Pituitary Society convened during
the 9th International Pituitary Congress in San Diego, California. Members of this committee …

Hyperprolactinemia is one of the most frequently diagnosed clinical disorders in routine
endocrine practice. Any process interfering with dopamine synthesis, its transport to the …

Polycystic ovary syndrome (PCOS) and hyperprolactinemia (HPRL) are the two most
common etiologies of anovulation in women. Since the 1950s, some authors think that there …

Background: Macroprolactin (big big prolactin) has reduced bioactivity and is measured by
immunoassays for prolactin when it accumulates in the plasma of some individuals. We …

Objective: The aim of the study was to evaluate clinical and laboratorial features of 1234
patients with different etiologies of hyperprolactinemia, as well as the response of 388 …

Serum prolactin is frequently measured when investigating patients with reproductive
disorders and elevated concentrations are found in up to 17% of such cases. Clinical …

The anterior pituitary hormone PRL was identified in animal species as early as 19331 but
only purified in humans in 1972. 2 Since then, the clinical syndrome of hyperprolactinaemia …

Background: Macroprolactin has reduced bioactivity in vivo and accumulates in the sera of
some subjects, resulting in pseudo-hyperprolactinemia and consequent misdiagnosis …