Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Integrated “lab-on-a-chip” microfluidic systems for isolation, enrichment, and analysis of cancer biomarkers

S Surappa, P Multani, U Parlatan, PD Sinawang… - Lab on a Chip, 2023 - pubs.rsc.org
The liquid biopsy has garnered considerable attention as a complementary clinical tool for
the early detection, molecular characterization and monitoring of cancer over the past …

Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications

M Yu, S Hu, B Tang, H Yang, D Sun - Biotechnology Advances, 2023 - Elsevier
Genetically engineered microbes, especially Escherichia coli, have been widely used in the
biosynthesis of proteins and metabolites for medical and industrial applications. As a …

Detection of prostate specific antigen in whole blood by microfluidic chip integrated with dielectrophoretic separation and electrochemical sensing

X Wang, X He, Z He, L Hou, C Ge, L Wang, S Li… - Biosensors and …, 2022 - Elsevier
The efficient detection of cancer markers has faced many challenges, such as severe
interference, complicated and time-consuming operation, low sensitivity and so on. In this …

Microfluidic strategies for extracellular vesicle isolation: towards clinical applications

A Meggiolaro, V Moccia, P Brun, M Pierno, G Mistura… - Biosensors, 2022 - mdpi.com
Extracellular vesicles (EVs) are double-layered lipid membrane vesicles released by cells.
Currently, EVs are attracting a lot of attention in the biological and medical fields due to their …

Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

CM Abreu, B Costa-Silva, RL Reis, SC Kundu… - Lab on a Chip, 2022 - pubs.rsc.org
Extracellular vesicles (EVs) are small lipidic particles packed with proteins, DNA, messenger
RNA and microRNAs of their cell of origin that act as critical players in cell–cell …

Applications of dielectrophoresis in microfluidic-based exosome separation and detection

M Lan, F Yang - Chemical Engineering Journal, 2024 - Elsevier
Exosomes are small vesicles secreted by most cells with contents such as primitive cell
proteins, lipids, and RNAs, which play a key role in cell communication and could be …

Advanced manufacturing of nanoparticle formulations of drugs and biologics using microfluidics

Y Shen, H Gwak, B Han - Analyst, 2024 - pubs.rsc.org
Numerous innovative nanoparticle formulations of drugs and biologics, named nano-
formulations, have been developed in the last two decades. However, methods for their …

Microfluidic systems for the analysis of blood‐derived molecular biomarkers

OG Chavez‐Pineda, R Rodriguez‐Moncayo… - …, 2022 - Wiley Online Library
Biomarkers are relevant indicators of the physiological state of an individual. Although
biomarkers can be found in diseased tissue and different biofluids, sampling from blood …

Multi‐Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single‐Cell Heterogeneity

F Song, C Wang, C Wang, J Wang, Y Wu… - Small …, 2022 - Wiley Online Library
Cellular phenotypic and functional heterogeneities have advanced cancer evolution and
treatment resistance. Although exosome‐bound proteins reflect cellular functions, single …