Diabetic vascular diseases: molecular mechanisms and therapeutic strategies

Y Li, Y Liu, S Liu, M Gao, W Wang, K Chen… - Signal transduction and …, 2023 - nature.com
Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Current understanding of the molecular and cellular pathology of diabetic retinopathy

DA Antonetti, PS Silva, AW Stitt - Nature Reviews Endocrinology, 2021 - nature.com
Diabetes mellitus has profound effects on multiple organ systems; however, the loss of
vision caused by diabetic retinopathy might be one of the most impactful in a patient's life …

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression

TT van Sloten, S Sedaghat, MR Carnethon… - The lancet Diabetes & …, 2020 - thelancet.com
Adults with type 2 diabetes are at an increased risk of develo** certain brain or mental
disorders, including stroke, dementia, and depression. Although these disorders are not …

Screening for diabetic retinopathy: new perspectives and challenges

S Vujosevic, SJ Aldington, P Silva… - The Lancet Diabetes & …, 2020 - thelancet.com
Although the prevalence of all stages of diabetic retinopathy has been declining since 1980
in populations with improved diabetes control, the crude prevalence of visual impairment …

[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

A deep-learning system for the assessment of cardiovascular disease risk via the measurement of retinal-vessel calibre

CY Cheung, D Xu, CY Cheng… - Nature biomedical …, 2021 - nature.com
Retinal blood vessels provide information on the risk of cardiovascular disease (CVD). Here,
we report the development and validation of deep-learning models for the automated …

Spectral-domain OCT measurements in Alzheimer's disease: a systematic review and meta-analysis

VTT Chan, Z Sun, S Tang, LJ Chen, A Wong, CC Tham… - Ophthalmology, 2019 - Elsevier
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye. The
relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease …

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease

X Hadoux, F Hui, JKH Lim, CL Masters, A Pébay… - Nature …, 2019 - nature.com
Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the
retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve …

Hypertensive eye disease

CY Cheung, V Biousse, PA Keane… - Nature Reviews …, 2022 - nature.com
Hypertensive eye disease includes a spectrum of pathological changes, the most well
known being hypertensive retinopathy. Other commonly involved parts of the eye in …