Turnitin
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Using clusterProfiler to characterize multiomics data
With the advent of multiomics, software capable of multidimensional enrichment analysis
has become increasingly crucial for uncovering gene set variations in biological processes …
has become increasingly crucial for uncovering gene set variations in biological processes …
SOX17 enables immune evasion of early colorectal adenomas and cancers
A hallmark of cancer is the avoidance of immune destruction. This process has been
primarily investigated in locally advanced or metastatic cancer,–; however, much less is …
primarily investigated in locally advanced or metastatic cancer,–; however, much less is …
Cell-type-specific CAG repeat expansions and toxicity of mutant Huntingtin in human striatum and cerebellum
Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT)
CAG tract are key features of Huntington's disease (HD). However, the relationships among …
CAG tract are key features of Huntington's disease (HD). However, the relationships among …
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors
Tumor-specific CD8+ T cells are frequently dysfunctional and unable to halt tumor growth.
We investigated whether tumor-specific CD4+ T cells can be enlisted to overcome CD8+ T …
We investigated whether tumor-specific CD4+ T cells can be enlisted to overcome CD8+ T …
Histone lactylation couples cellular metabolism with developmental gene regulatory networks
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that
metabolic reprogramming drives changes in cell identity by affecting gene expression …
metabolic reprogramming drives changes in cell identity by affecting gene expression …
Zygotic genome activation by the totipotency pioneer factor Nr5a2
Life begins with a switch in genetic control from the maternal to the embryonic genome
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
during zygotic genome activation (ZGA). Despite its importance, the essential regulators of …
[HTML][HTML] Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems
Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human
cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the …
cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the …
Selective vulnerability of layer 5a corticostriatal neurons in Huntington's disease
The properties of the cell types that are selectively vulnerable in Huntington's disease (HD)
cortex, the nature of somatic CAG expansions of mHTT in these cells, and their importance …
cortex, the nature of somatic CAG expansions of mHTT in these cells, and their importance …
[HTML][HTML] Thirteen years of clusterProfiler
When the human genome was fully sequenced in 2003, research focus shifted to functional
genomics, particularly the spatiotemporal expression of genes, which is crucial for …
genomics, particularly the spatiotemporal expression of genes, which is crucial for …
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
We set out to exhaustively characterize the impact of the cis-chromatin environment on
prime editing, a precise genome engineering tool. Using a highly sensitive method for …
prime editing, a precise genome engineering tool. Using a highly sensitive method for …