Pancreatic cancer (PC) is a leading cause of cancer related mortality on a global scale. The
disease itself is associated with a dismal prognosis, partly due to its silent nature resulting in …

Early onset colorectal cancers, defined as arising before 50 years of age, are a growing
health hazard in western and eastern countries alike. The incidence of colon and rectal …

Colorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours
responding to available therapies, requiring a better molecular understanding of the disease …

Colorectal cancers are believed to arise predominantly from adenomas. Although these
precancerous lesions have been subjected to extensive clinical, pathologic, and molecular …

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer,
characterized by high tumor heterogeneity and a poor prognosis. Inter-and intra-tumoral …

Gastric cancer (GC), one of the most common human cancers, can be classified into gastric
or intestinal phenotype according to mucin expression. TP 53 mutation, allelic deletion of the …

NF-κB plays a central, proinflammatory role in chronic intestinal inflammation, yet recent
work suggests a predominantly protective function for this transcription factor group in some …

Abstract Aldehyde dehydrogenase 1 (ALDH1) has been shown to serve as a marker for
cancer‐initiating cells (CICs), but little is known about the regulation of the CIC functions of …

The regenerating (Reg) protein family comprises C-type lectin-like proteins discovered
independently during pancreatitis and pancreatic islet regeneration. However, an increasing …

Regenerating gene (REG) family proteins serve as multifunctional secretory molecules with
trophic, antiapoptotic, anti-inflammatory, antimicrobial and probably immuno-regulatory …