Peripheral nerve injury, scarring, and recovery
ML Wang, M Rivlin, JG Graham… - Connective tissue …, 2019 - Taylor & Francis
Peripheral nerve injuries (PNI) resulting from trauma can be severe and permanently
debilitating. Despite the armamentarium of meticulous microsurgical repair techniques that …
debilitating. Despite the armamentarium of meticulous microsurgical repair techniques that …
Transforming growth factor-β receptors: versatile mechanisms of ligand activation
Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome
Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and has a
largely unknown underlying biology. In a genome-wide association study of CTS (48,843 …
largely unknown underlying biology. In a genome-wide association study of CTS (48,843 …
Systemic inflammatory markers in neuropathic pain, nerve injury, and recovery
The role that inflammation plays in human nerve injury and neuropathic pain is incompletely
understood. Previous studies highlight the role of inflammation in the generation and …
understood. Previous studies highlight the role of inflammation in the generation and …
Administration of purified exosome product in a rat sciatic serve reverse autograft model
Background: The nerve autograft remains the gold standard when reconstructing peripheral
nerve defects. However, although autograft repair can result in useful functional recovery …
nerve defects. However, although autograft repair can result in useful functional recovery …
ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons
W Morita, SJB Snelling, K Wheway, B Watkins… - Scientific Reports, 2019 - nature.com
Diseased and injured tendons develop fibrosis, driven by factors including TGF-β, BMPs and
CTGF. IL-1β and its signal transducer Erk1/2 are known to regulate TGF-β expression in …
CTGF. IL-1β and its signal transducer Erk1/2 are known to regulate TGF-β expression in …
Clinical evidence and mechanisms of growth factors in idiopathic and diabetes-induced carpal tunnel syndrome
Carpal tunnel syndrome (CTS) is an entrapment neuropathy caused by compression and
irritation of the median nerve, which travels through the carpal tunnel in the wrist. Increased …
irritation of the median nerve, which travels through the carpal tunnel in the wrist. Increased …
Association between hormone replacement therapy and carpal tunnel syndrome: a nationwide population-based study
HC Tang, YY Cheng, HR Guo - BMJ open, 2022 - bmjopen.bmj.com
Objective Carpal tunnel syndrome (CTS) is the most common compressive focal
mononeuropathy, and the increased incidence in postmenopausal and pregnant women …
mononeuropathy, and the increased incidence in postmenopausal and pregnant women …
Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse‐induced median mononeuropathy
MF Barbe, BA Hilliard, M Amin… - Journal of …, 2020 - Wiley Online Library
Encapsulation of median nerves is a hallmark of overuse‐induced median mononeuropathy
and contributes to functional declines. We tested if an antibody against CTGF/CCN2 (termed …
and contributes to functional declines. We tested if an antibody against CTGF/CCN2 (termed …
Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome
Fibrosis of the subsynovial connective tissue (SSCT) in carpal tunnel syndrome (CTS)
patients is increasingly recognized as an important aspect of CTS pathophysiology. In this …
patients is increasingly recognized as an important aspect of CTS pathophysiology. In this …