Beyond the consolidated role in degrading and recycling cellular waste, the autophagic-and
endo-lysosomal systems play a crucial role in extracellular release pathways. Lysosomal …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis …

Following acute kidney injury (AKI), renal tubular cells may stimulate fibroblasts in a
paracrine fashion leading to interstitial fibrosis, but the paracrine factors and their regulation …

Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that
affects the skin and many other organs. Its pathophysiology is complex and involves an early …

Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of
cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy …

Although best understood as a degradative pathway, recent evidence demonstrates
pronounced involvement of the macroautophagic/autophagic molecular machinery in …

Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of
fibroblasts, however, may lead to tissue fibrosis with organ dysfunction. Although several …

The serine/threonine kinase, PINK1, and the E3 ubiquitin ligase, Parkin, are known to
facilitate LC3-dependent autophagosomal encasement and lysosomal clearance of …

Simple Summary Transforming growth factor beta (TGF-β) is a multifunctional cytokine that
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …