Cav1. 2 Ca2+ channels, a type of voltage-gated L-type Ca2+ channel, are ubiquitously
expressed, and the predominant Ca2+ channel type, in working cardiac myocytes. Cav1. 2 …

L-type voltage-gated Ca2+ channels (CaV1. 2 and CaV1. 3, called CaV) interact with the
Ca2+ sensor proteins, calmodulin (CaM) and Ca2+ binding Protein 1 (CaBP1), that …

The function of the human voltage-gated sodium channel NaV1. 5 is regulated in part by
intracellular calcium signals. The ubiquitous calcium sensor protein calmodulin (CaM) is an …

The L‐type Ca2+ channel CaV1. 2 governs gene expression, cardiac contraction, and
neuronal activity. Binding of α‐actinin to the IQ motif of CaV1. 2 supports its surface …

Calmodulin (CaM) binding to the intracellular C-terminal tail (CTT) of the cardiac L-type
Ca2+ channel (CaV1. 2) regulates Ca2+ entry by recognizing sites that contribute to …

The L-type voltage-gated calcium channel Cav1. 2 is important for excitation-contraction
coupling in the heart, as well as CREB-mediated transcription in the brain. The ubiquitous …

In this study, we investigated the roles of calmodulin kinase II (CaMKII) and calmodulin
(CaM) in the reversal of run-down of L-type Ca 2+ channels. Single Ca 2+-channel activities …

L-type Ca2+ channels have two opposing forms of autoregulatory feedback, Ca2+-
dependent facilitation (CDF) and Ca2+-dependent inactivation (CDI), in response to …

The present study is to investigate the mechanism by which ATP regulates Cav1. 2 channel
activity. Ventricular tissue was obtained from adult guinea pig hearts using collagenase …

Abstract Mutations of Gln41 and Lys75 with nonpolar residues in the N-terminal domain of
calmodulin (N-Cam) revealed the importance of solvation energetics in conformational …