The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …

BACKGROUND Induction of innate immune memory, also termed trained immunity, by the
antituberculosis vaccine bacillus Calmette-Guérin (BCG) contributes to protection against …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

The classical view that only adaptive immunity can build immunological memory has
recently been challenged. Both in organisms lacking adaptive immunity as well as in …

Low-grade systemic inflammation is a key pathophysiological component of atherosclerotic
cardiovascular disease (CVD), and long-term activation of myeloid cells is thought to be …

Innate immune memory, or trained immunity, has recently been described to be an important
property of cells of the innate immune system. Due to the increased interest in this important …

Highlights•Cells from the innate immune system can undergo functional reprogramming.•
Trained immunity involves rewiring the intracellular immune signaling of innate immune …

Rationale: Exposure to high catecholamine levels is associated with inflammatory changes
of myeloid cells and atherosclerosis, but the underlying mechanisms are only partly …

Atherosclerosis, a chronic inflammatory disease of the arterial wall, is among the leading
causes of morbidity and mortality worldwide. The persistence of low-grade vascular …