The role of hypoxia-inducible factor post-translational modifications in regulating its localisation, stability, and activity
A Albanese, LA Daly, D Mennerich… - International journal of …, 2020 - mdpi.com
The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …
availability. When oxygen becomes limiting, the central transcription factors of the pathway …
cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
H Zhang, Y Liu, J Liu, J Chen, J Wang, H Hua… - Journal of Hematology & …, 2024 - Springer
Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …
number of genetic and environmental factors. The tumor microenvironment (TME), which …
Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy
Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …
Succinate dehydrogenase and MYC-associated factor X mutations in pituitary neuroendocrine tumours
Pituitary neuroendocrine tumours (PitNETs) associated with paragangliomas or
phaeochromocytomas are rare. SDHx variants are estimated to be associated with 0.3–1.8 …
phaeochromocytomas are rare. SDHx variants are estimated to be associated with 0.3–1.8 …
In vivo real-time monitoring of the development of hypoxia and angiogenesis in cervical cancer
D Chen, W Wang, Q Zhu, Q Wang, D Quan… - Chemical Engineering …, 2023 - Elsevier
The growth of solid tumors is inevitably accompanied by hypoxia and angiogenesis.
Understanding the true state of tissue hypoxia and angiogenesis during tumor progression …
Understanding the true state of tissue hypoxia and angiogenesis during tumor progression …
Rh‐CSF1 attenuates oxidative stress and neuronal apoptosis via the CSF1R/PLCG2/PKA/UCP2 signaling pathway in a rat model of neonatal HIE
X Hu, S Li, DM Doycheva, L Huang… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress (OS) and neuronal apoptosis are major pathological processes after
hypoxic‐ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to …
hypoxic‐ischemic encephalopathy (HIE). Colony stimulating factor 1 (CSF1), binding to …
Identification of diagnostic gene biomarkers and immune infiltration in patients with diabetic kidney disease using machine learning strategies and bioinformatic …
S Fu, Y Cheng, X Wang, J Huang, S Su, H Wu… - Frontiers in …, 2022 - frontiersin.org
Objective Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and
end-stage renal disease worldwide. Early diagnosis is critical to prevent its progression. The …
end-stage renal disease worldwide. Early diagnosis is critical to prevent its progression. The …
Reciprocal regulation of MAGED2 and HIF-1α augments their expression under hypoxia: role of cAMP and PKA type II
E Seaayfan, S Nasrah, L Quell, A Radi, M Kleim… - Cells, 2022 - mdpi.com
Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many
genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation …
genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation …
The role of reversible protein phosphorylation in regulation of the mitochondrial electron transport system during hypoxia and reoxygenation stress in marine bivalves
Fluctuations in the ambient oxygen concentrations represent a major stressor for aerobic
organisms causing ATP deficiency during hypoxia and excessive production of reactive …
organisms causing ATP deficiency during hypoxia and excessive production of reactive …
The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling
Y Fu, S Huang, R Pan, X Chen, T Liu, R Zhang… - Communications …, 2025 - nature.com
Phosphodiesterase 4D interacting protein (PDE4DIP) is a Golgi/centrosome-associated
protein that plays critical roles in the regulation of microtubule dynamics and maintenance of …
protein that plays critical roles in the regulation of microtubule dynamics and maintenance of …