This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Objectives A systematic review and meta-analysis to determine the association between
active maternal smoking and cleft lip and palate etiology. Data sources Medline, Embase …

BackgroundSmoking prevalence is higher amongst individuals with schizophrenia and
depression compared with the general population. Mendelian randomisation (MR) can …

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Obesity is an established risk factor for cancer. However, conventional measures like body
mass index lack precision in assessing specific tissue quantities, particularly of the two …

Mendelian randomization uses genetic variants as instrumental variables to make causal
inferences about the effect of a risk factor on an outcome [1, 2]. If a genetic variant satisfies …

Mendelian randomization (MR) is a valuable tool for inferring causal relationships among a
wide range of traits using summary statistics from genome-wide association studies …

Objectives To investigate whether the association between subjective wellbeing (subjective
happiness and life satisfaction) and cardiometabolic health is causal. Design Two sample …

Background Despite the established association between obesity and cancer risk, it remains
unclear whether visceral obesity is causally related to cancer risk and whether it is more pro …

Mendelian randomization (MR) uses genetic variants as instrumental variables to
investigate the causal effect of a risk factor on an outcome. A collider is a variable influenced …