The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

Macrophages are versatile and heterogeneous innate immune cells undertaking central
functions in balancing immune responses and tissue repair to maintain homeostasis. This …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

In metazoan organisms, cell competition acts as a quality control mechanism to eliminate
unfit cells in favour of their more robust neighbours,. This mechanism has the potential to be …

Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …

T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

Abstract Tumour-associated macrophages (TAMs), as one of the most abundant tumour-
infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

The organization of immune cells in human tumors is not well understood. Immunogenic
tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T …