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COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review
Coronavirus disease-19 (COVID-19) has been regarded as an infective-inflammatory
disease, which affects mainly lungs. More recently, a multi-organ involvement has been …
disease, which affects mainly lungs. More recently, a multi-organ involvement has been …
Red blood cell storage lesion: causes and potential clinical consequences
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …
Intravascular hemolysis and the pathophysiology of sickle cell disease
Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …
Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics
During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
Red blood cell function and dysfunction: redox regulation, nitric oxide metabolism, anemia
Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …
Mechanisms of haemolysis-induced kidney injury
Intravascular haemolysis is a fundamental feature of chronic hereditary and acquired
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
haemolytic anaemias, including those associated with haemoglobinopathies, complement …
Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in
which neutrophil activation plays a major role. The disease is associated with chronic …
which neutrophil activation plays a major role. The disease is associated with chronic …
Anemia: progress in molecular mechanisms and therapies
Anemia is a major source of morbidity and mortality worldwide. Here we review recent
insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms …
insights into how red blood cells (RBCs) are produced, the pathogenic mechanisms …
Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development
Hemolysis, which occurs in many disease states, can trigger a diverse pathophysiologic
cascade that is related to the specific biochemical activities of free Hb and its porphyrin …
cascade that is related to the specific biochemical activities of free Hb and its porphyrin …
Haptoglobin: From hemoglobin scavenging to human health
Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …