Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Phagocyte-derived reactive oxygen and nitrogen species are of crucial importance for host
resistance to microbial pathogens. Decades of research have provided a detailed …

The O2 J generated by this enzyme serves as the starting material for the production of a
vast assortment of reactive oxidants, including oxidized halogens, free radicals, and singlet …

Neutrophils and other phagocytes manufacture O2−(superoxide) by the one-electron
reduction of oxygen at the expense of NADPH. Most of the O2− reacts with itself to form …

Highlights•Phagocyte NOX2 NADPH oxidase generates oxidants.•Optimal antimicrobial
action in phagosomes depends on oxidants.•Precise mechanisms of oxidant-dependent …

Chronic granulomatous disease (CGD) is a recessive disorder characterized by a defective
phagocyte respiratory burst oxidase, life–threatening pyogenic infections and inflammatory …

We determined the role of Phospholipase Dα1 (PLDα1) and its lipid product phosphatidic
acid (PA) in abscisic acid (ABA)-induced production of reactive oxygen species (ROS) in …

The neutrophil is a key player in immunity, and its activities are essential for the resolution of
infections. Neutrophil-pathogen interactions usually trigger a large arsenal of antimicrobial …