Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

Ascending and descending information is relayed through the thalamus via strong,“driver”
pathways. According to our current knowledge, different driver pathways are organized in …

Hereditary cerebellar ataxias (CAs) are neurodegenerative disorders clinically characterized
by a cerebellar syndrome, often accompanied by other neurological or non-neurological …

A major synaptic input to the thalamus originates from neurons in cortical layer 6 (L6);
however, the function of this cortico–thalamic pathway during sensory processing is not well …

Absence Epilepsy (AE) is a prototypic epileptic syndrome that develops during brain
maturation but cannot be fully explored in human patients. Genetic animal models …

Pain is a quite frequent complaint accompanying numerous pathologies. Among these
pathological cases, numerous neuropathies are retrieved with identified etiologies …

Background Spinocerebellar ataxia (SCA) is a genetically heterogeneous disease. To date,
36 dominantly inherited loci have been reported, and 31 causative genes have been …

T-type calcium channels represent a key pathway for Ca 2+ entry near the resting
membrane potential. Increasing evidence supports a unique role of these channels in fast …

Surprisingly, the concept of sleep, its necessity and function, the mechanisms of action, and
its elicitors are far from being completely understood. A key to sleep function is to determine …