The study of pain development has come into its own. Rea** the rewards of years of
developmental and molecular biology, it has now become possible to translate fundamental …

Before the 1970s, the medical literature is essentially devoid of any formal reviews or
research specifically addressing the management of pain in children. The limited discussion …

Invasive procedures that would be painful in children and adults are frequently performed on
infants admitted to the neonatal intensive care unit. This article discusses sensory responses …

Does pain or tissue damage in early life lead to hyperalgesia persisting into childhood? We
performed a cross-sectional study in 164 infants to investigate whether major surgery within …

Glutamate, the major excitatory neurotransmitter in the central nervous system, activates
three different receptors that directly gate ion channels, namely receptors for AMPA (α-amino …

The mechanisms by which infants and children process pain should be viewed within the
context of a develo** sensory nervous system. The study of the neurophysiological …

Pain often occurs in criti-cal care patients and is one of the most clinically challenging
problems for critical care nurses. Pain and discomfort in these patients can be due to …

The dorsal horn of the spinal cord in the newborn rat is characterized by large cutaneous
mechanoreceptive fields, a predominance of A‐fibre synaptic inputs and diffuse primary …

The change in synaptic inputs through primary afferent C-and A-fibers during postnatal
development was examined in substantia gelatinosa neurons of a rat spinal cord slice with …

The withdrawal reflex system has been extensively used as a model system for studies of
pain related mechanisms, sensorimotor integration, learning and memory. For a long time …