Subsequent to the discovery of insulin 100 years ago, great strides have been made in
understanding its function, especially in the brain. It is now clear that insulin is a critical …

Members of the two-pore domain K+ channel (K 2P) family are increasingly recognized as
being potential targets for therapeutic drugs and could play a role in the diagnosis and …

Synaptogenesis plays a central role in associative learning and memory. The biochemical
pathways that underlie synaptogenesis are complex and incompletely understood …

Neonatal isoflurane exposure in rodents disrupts hippocampal cognitive functions, including
learning and memory, and astrocytes may have an important role in this process. However …

Major depressive disorder (MDD) refers to a widespread psychiatric disorder. Astrocytes
play a pivotal role in regulating inflammation which is a well-acknowledged key component …

Two-pore domain potassium channel TREK-1 was known to play an important role in
neuroprotection, especially in acute cerebral ischemia. In the present study we found that 3 …

Post-operative cognitive dysfunction (POCD) has been widely reported, especially in elderly
patients. An association between POCD and inhalational anesthetics, such as isoflurane …

Background There are growing concerns that anaesthetic exposure can cause extensive
apoptotic degeneration of neurons and the impairment of normal synaptic development and …

Aim: Recent studies have shown that the two-pore-domain potassium channel TREK-1 is
involved in the proliferation of neural stem cells, astrocytes and human osteoblasts. In this …

Abstract TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain
potassium (K2p) channel and is widely expressed in the brain. TREK-1 knockout mice were …